Retatrutide: Literature on Triple Receptor Agonism
Why retatrutide appears in the literature
Retatrutide (also designated LY3437943) is a synthetic peptide reported in the peer-reviewed literature as an agonist at three incretin and metabolic receptors simultaneously: the glucagon-like peptide-1 receptor (GLP-1R), the glucose-dependent insulinotropic polypeptide receptor (GIPR), and the glucagon receptor (GCGR). This distinguishes it from single-target and dual-target analogues discussed elsewhere in the incretin literature.
Structural characterization
Cryo-electron microscopy work published in Cell Discovery (2024) resolved retatrutide-bound complexes at all three receptors, describing how a single backbone accommodates three distinct orthosteric pockets. These structures are frequently cited in receptor-pharmacology work examining how sequence substitutions and lipidation influence relative potency across the three targets.
Clinical literature context
A phase 2, double-blind, randomized, placebo-controlled trial reported in the New England Journal of Medicine (2023) evaluated dose–response relationships for the compound over 48 weeks. Brickell Labs references this literature strictly as scientific background; it does not constitute guidance for use of our materials.
Handling and analytical notes
Like other lyophilized peptide reference materials, retatrutide is supplied for in-vitro research and laboratory development use only. Store the sealed vial as printed on the label, protect from light, and confirm identity and purity against the lot-specific certificate of analysis before beginning any assay. Mass and purity data for each lot are published on the product page.
Selected references
- Jastreboff AM et al. Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial. N Engl J Med. 2023.
- Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide. Cell Discovery. 2024.
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